Impurity profiling according to ICH and pharmacopeias

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Metrohm International Headquarters
Metrohm AG
Ionenstrasse
CH-9100 Herisau
Switzerland
Contact us How to find us Metrohm worldwide
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Environmental
Find out what Metrohm has to offer for environmental analysis in air, soil, and water.
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Petrochemicals / biofuel
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Metrohm International Headquarters
Metrohm AG
Ionenstrasse
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Looking for a titrator?
Are you looking for the right titrator for your requirements?
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OMNIS
New titration system for the modern laboratory: faster analysis, safer chemical handling, compliant software, more automation.
Titrando
High-end potentiometric titrator that meets any requirements: flexible, compliant, customizable, and automatable
Ti-Touch
Compact, easy-to-use potentiometric titrator for a wide range of routine titrations
Eco Titrator
New basic titrator for all standard potentiometric titration applications
Titrino plus
Entry-level, versatile potentiometric titrator for basic applications
Titrotherm
Thermometric titrator for fast determinations if potentiometric titration cannot be applied
Looking for a KF titrator?
Are you looking for the right KF titrator for your requirements?
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OMNIS KF
New volumetric Karl Fischer titrator for safe, easy, and fast water content determination
KF Titrando
High-end titrators for determining any water content from 0.001 to 100%
KF Ti-Touch
Compact, stand-alone volumetric (> 0.1% water) or coulometric (down to 0.001% water) titrator with integrated touch-screen control unit
Eco KF Titrator
Basic volumetric Karl Fischer titrator for simple, safe, and reliable routine water content determinations
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KF Titrino plus
Entry-level titrator for coulometric (water content: 0.001 to 1%) or volumetric (up to 100%) water determination
Coulometers
Our range of coulometers for the determination of low water contents (0.001 to 1%).
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Titrino Coulometer
Basic coulometer for determining low water contents (down to 0.001%)
Gas Analyzer
All-inclusive system for water determination in liquefied and permanent gases
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940 Professional IC Vario
High-end ion chromatography system for research applications and method development
930 Compact IC Flex
Compact ion chromatography system for routine analysis
Eco IC
Entry-level ion chromatograph for water analysis and utilization as a training tool.
Hyphenated techniques
Extend the scope of ion chromatography by interfacing your Metrohm IC with various sampling system and detection techniques
IC software
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IC vs. HPLC
IC is the method of choice when HPLC fails.
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Columns

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Looking for a meter?
Find the right meter for your pH, conductivity, oxygen, or ion measurements
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912/913/914 pH/DO/Conductometer
Easy-to-use meters for use in the lab and in the field
780/781 pH/Ion meter
Advanced pH and ion meters for use in the lab
867/856 Modules
High-end modules for customized pH, ion, and conductivity measurement
Overview of our spectroscopy product range
Find the right spectrometer for your requirements.
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Fast QC with NIRS
Learn how NIRS can boost your productivity and reduce costs in your QC lab.
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Near-infrared Spectroscopy Analyzers
Near-infrared spectroscopy analyzers for routine analysis of chemical and physical properties
NIRS Process Analyzers
- NIRS Process Analyzers PRO
- NIRS XDS Process Analyzers
Metrohm Instant Raman Analyzers
Handheld spectrometer for quick and easy identification of unknown substances
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B&W Tek Mobile Spectroscopy Solutions
B&W Tek offers a complete line of high performance laboratory, portable and handheld Raman systems
Overview of our VA and CVS solutions
Find the right VA or CVS system for your requirements here.
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Professional VA/CVS Instruments
Advanced VA systems with high-performance viva software for determining traces of heavy metals with polarography and voltammetry with high sensitivity
Portable VA Analyzer
Portable voltammetric analyzer for the determination of trace levels of arsenic, mercury, and copper in water
Sample preparation

Process VA
Pioneers in Process Analysis
We love to tackle analytical challenges at Metrohm Process Analytics.
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Process Analyzer overview
Learn more about our families of Process Analyzers
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2060 Process Analyzers
Modular analyzer platform for ultimate flexibility in customized process monitoring.
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MARGA
Fully autonomous system monitoring ions in aerosols and gases in ambient air
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NIRS XDS Process Analyzers
Multi-channel analyzer for nondestructive real-time spectroscopic analysis
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NIRS Process Analyzers PRO
Analyzer for continuous nondestructive analysis by means of contact probes or noncontact measurements above a conveyor belt or through a glass window
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2035 Process Analyzers
Process analyzers available as potentiometric, photometric, and thermometric versions and optional additional pH and conductivity measurement
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202X Series – single-method Process Analyzers
Single-method process analyzers for water and wastewater monitoring with titration, pH, ISE, or photometry methods.
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ADI 204Y – Multifunctional Process Analyzers
Multifunctional process analyzers tailored to your requirements for multiparameter measurements and streams
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Process Ion Chromatograph
Taking high-precision Metrohm ion chromatography to an even higher level of autonomy, the Process IC can connect up to 20 sample streams and provide reliable multicomponent results for superior process control.
MPA Quality Service
Our quality service ranges from consulting and application support to installation, training, preventive maintenance and repair service.
Overview of Electrochemistry
Find the right electrochemical solution for your requirements.
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Compact Line
High-quality potentiostat/galvanostat instruments with a small footprint
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Modular Line
Modular potentiostat/galvanostat instruments for any requirements in electrochemical research
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Multichannel Line
Multichannel potentiostat/galvanostat instruments for simultaneous measurements
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Portable Line
Compact, PC-controlled portable potentiostat for education and basic applications
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Spectroelectrochemistry
Integrated solution for combined electrochemical and spectroscopic analysis.
Complementary products
Electrochemistry electrodes
Software
- NOVA software and SDK
- DropView software
Stability measurement overview
Learn more about our solutions for stability measurement.
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Rancimat
Instrument for determining the oxidation stability of natural oils and fats
Biodiesel Rancimat
Instrument for determining the oxidation stability of biodiesel and biodiesel blends
PVC Thermomat
Instrument for determining the thermostability of PVC
Liquid Handling Overview
Learn more about our Liquid Handling solutions.
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Eco Dosimat
Modern liquid handling system for Swiss-made precision and accuracy at an affordable price.
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846 Dosing Interface
Liquid handling instrument for standalone use or integration into existing Metrohm systems
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Dosimat plus
Manually controlled, high-precision instrument for all liquid handling tasks
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Accessory Finder
Find dosing units, tubes, glassware, beakers, and other accessories and spare parts.

Column Finder
Find analytical, trap, and guard columns for the determination of anions and cations.

Electrode Finder
Find the suitable electrode for your application: titration, IC, pH measurement, VA, CVS, electrochemistry and more.

Software Finder
Find Metrohm software for titration, IC, VA/CVS, stability measurement, electrochemistry, spectroscopy, and more.
OMNIS KF – Safe, easy, and fast Karl Fischer titration
Karl Fischer titration has never been better:
- Safe handling of reagents,
- Easier titration through automatic titration start
- Time savings through automated procedures
Discover OMNIS KF

Application/parameters	USP monograph	Citation frequency of the test method	Test methods
pH value	USP<791>	In approx. 1400 USP monographs In approx. 250 NF monographs	pH value measurement
Conductivity	USP<645>	Ultrapure water (pharma)	Conductivity measurement
Various APIs Various excipients	USP<541>	In approx. 250 USP monographs In approx. 130 NF monographs	Titration
Water content	USP<921> Method I Ph. Eur. 2.5.12 Ph. Eur. 2.5.32	In approx. 630 USP monographs In approx. 110 NF monographs In approx. 1080 monographs In approx. 150 monographs	Karl Fischer titration
Various APIs Various excipients Amino acids	USP<621> USP<1065> USP<1052>, Method I	In approx. 58 USP and 13 NF monographs In 3 NF monographs In 5 USP monographs	Ion chromatography
Various APIs Thiomersal Heavy metals	USP<801> USP<341> USP<232>, <233>	In 8 USP monographs Various antimicrobial agent determinations In approx. 780 USP and 230 NF monographs	Polarography
Various parameters	USP<1119> Ph. Eur. 2.2.40	Various	Near-infrared spectroscopy
Various parameters	USP<1120>	Various	Raman spectroscopy

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2/5/2021

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2/5/2021

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